epitope specific ab
case studies
Published example: Computationally designed epitope specific Multibody binding a cryptic epitope
Challenge: Designing an Ab for a cryptic epitope - not exposed to solvent in the native conformation*
N terminus covers epitope in the native conformation and desired binding site (epitope) is hidden
Biolojic’s solution - epitope specific Antibody which moves the N terminus and binds at the desired site, leading to the desired biological effect
Published in: Computational design of epitope specific functional antibodies, Cell Reports, Nov 2018
Crystal structure of Biolojic’s Antibody and binding site
Designed agonist for autoimmune diseases, developed in partnership with Nektar
“Biolojic […] announced that it has entered into a research collaboration and license option agreement with Nektar Therapeutics to discover and develop agonistic antibodies that activate a novel and previously un-drugged target for the treatment of autoimmune disease.”
AULOS - Conditional agonist / antagonist for IO
“[Aulos] lead antibody candidate AU-007 binds endogenous IL-2 in such a way as to physically block the ability of IL-2 to bind with the α-chain on regulatory T cells. This approach may also make the most of a complex IL-2 feedback cycle.”